Argireline is a trademark owned by Barcelona-based Lipotec. It is a proprietary solution of Acetyl Hexapeptide-8. Controlled studies have shown that Argireline improves the appearance of facial areas prone to developing dynamic folds, including around the eyes and in the forehead area. Note: Studies have shown that the water content of formulations does impact the utility level of topical Argireline and specifically that higher water content results in better utility. This formulation is water-based and avoids oils, esters and silicones. Directions Apply a few drops on the forehead and around the eyes twice daily before heavier treatments.