High-Strength Vitamin and Mineral Blemish Formula Niacinamide (Vitamin B3) is indicated to reduce the appearance of skin blemishes and congestion. A high 10% concentration of this vitamin is supported in the formula by zinc salt of pyrrolidone carboxylic acid to balance visible aspects of sebum activity. Contraindications: If topical Vitamin C is used as part of skincare, it should be applied at alternate times with this formula (ideally Vitamin C in the PM and this formula in the AM). Otherwise, Niacinamide can affect integrity of pure-form Vitamin C (L-Ascorbic Acid). Note: While Niacinamide and Zinc PCA reduce the look of blemishes and balance visible sebum activity, neither is a treatment for acne. For persistent acne-related conditions, we recommend the use of Benzoyl Peroxide and/or Retinoic Acid. We do not recommend the use of Salicylic Acid. This formulation can be used alongside acne treatments if desired for added visible skin benefits. Directions: Apply to entire face morning and evening before heavier creams.